MTHFR Daily is a comprehensive methylation multivitamin designed to fill nutritional gaps, support your body’s methylation pathways, and provide a complete daily foundation for energy, focus, and whole-body health.

• Supports Energy Metabolism — Methylated B vitamins are essential cofactors in the Krebs cycle and mitochondrial energy production. By providing B vitamins in their active forms, MTHFR Daily supports sustained, cellular-level energy without the crash of stimulants.
• Promotes Brain & Mood Health — Methylation is critical for the synthesis of neurotransmitters including serotonin, dopamine, and norepinephrine. Proper methylation support helps maintain mood stability, mental clarity, and cognitive performance.
• Supports Liver Detoxification — The liver’s phase II detoxification pathways depend heavily on methylation. MTHFR Daily provides the nutrients needed to support efficient liver detox and toxin .
• Strengthens Immune Function — A full spectrum of vitamins and minerals — including zinc, vitamin D, and vitamin C — supports robust immune defense and helps the body respond effectively to pathogens and environmental stressors.
• Supports Methylation Pathways — The MTHFR enzyme converts folate to its active form (5-MTHF). Those with MTHFR variants cannot efficiently perform this conversion. MTHFR Daily provides methylfolate and methylcobalamin — the pre-converted, active forms — bypassing this genetic bottleneck entirely.
• Promotes Cardiovascular Health — Impaired methylation leads to d homocysteine, a key risk factor for cardiovascular disease. Methylated B vitamins help regulate homocysteine levels and support healthy heart function.
• Supports Stress Resilience — Adaptogenic nutrients and adrenal-supporting vitamins help the body manage physical and mental stress more effectively, reducing the physiological burden of chronic stress.
• Promotes Healthy Cell Renewal — Methylation is essential for DNA synthesis and repair. Proper methylation support helps maintain healthy cell replication and reduces the risk of DNA damage accumulation over time.
• Full Spectrum Vitamins & Minerals — A complete daily multivitamin foundation covering all essential micronutrients — not just the methylation-specific ones — to fill nutritional gaps and support overall well-being.

What Is the MTHFR Gene?

MTHFR (methylenetetrahydrofolate reductase) is an enzyme encoded by the MTHFR gene. Its primary job is to convert folate (vitamin B9) from food and supplements into its active form — 5-methyltetrahydrofolate (5-MTHF) — which the body uses for methylation. An estimated 40–60% of the population carries one or more variants of the MTHFR gene (most commonly C677T or A1298C) that reduce this enzyme’s efficiency by 30–70%.

What Is Methylation?

Methylation is a fundamental biochemical process that occurs over a billion times per second in every cell of your body. It is involved in:

• DNA synthesis, repair, and gene expression regulation
• Neurotransmitter production (serotonin, dopamine, norepinephrine)
• Detoxification of hormones, toxins, and heavy metals
• Homocysteine regulation (cardiovascular protection)
• Immune system modulation
• Energy production via the mitochondria
• Healthy cell division and renewal

Why Standard Multivitamins Don’t Work for MTHFR

Most multivitamins contain folic acid (synthetic folate) and cyanocobalamin (synthetic B12) — forms that require the MTHFR enzyme to convert them into usable forms. For those with MTHFR variants, this conversion is impaired, meaning standard multivitamins may provide little to no benefit for methylation-dependent processes.

How MTHFR Daily Is Different

MTHFR Daily provides vitamins in their active, methylated forms — including methylfolate (5-MTHF) and methylcobalamin (active B12) — that bypass the MTHFR enzyme entirely and are immediately available for use by the body. This makes MTHFR Daily effective for everyone, but especially critical for those with MTHFR variants.

See the product label for the complete Supplement Facts panel with all ingredients and amounts.

Take as directed on the product label. MTHFR Daily is designed for consistent daily use as your complete multivitamin foundation.

• Take with food to minimize any potential stomach sensitivity and improve fat-soluble vitamin absorption
• taken in the morning to support energy and focus throughout the day
• Store in a cool, dry place away from direct sunlight and heat
• Keep out of reach of children
• Do not exceed serving size

Pro Tips:

• If you are new to methylated B vitamins, some individuals with MTHFR variants may experience a brief adjustment period — start with the dose and consult your healthcare provider if needed
• Pairs well with magnesium glycinate for comprehensive methylation and nervous system support
• Consistent daily use is essential — methylation support is cumulative and works over weeks and months of regular supplementation
• If you have had genetic testing confirming an MTHFR variant, discuss optimal dosing with your healthcare provider

Q: Do I need to have an MTHFR gene variant to benefit from MTHFR Daily?A: No — MTHFR Daily is beneficial for everyone. Methylated vitamins are more bioavailable and effective for all people, not just those with MTHFR variants. However, for those with confirmed MTHFR variants, MTHFR Daily is especially important because standard multivitamins containing folic acid and cyanocobalamin may not be effectively utilized.

Q: What makes MTHFR Daily different from a regular multivitamin?A: MTHFR Daily provides key vitamins in their active, methylated forms — including methylfolate (5-MTHF) and methylcobalamin — that bypass the MTHFR enzyme and are immediately usable by the body. Standard multivitamins typically use folic acid and cyanocobalamin, which require enzymatic conversion that may be impaired in a significant portion of the population.

Q: What is homocysteine and why does it matter?A: Homocysteine is an amino acid that, when d, is a significant risk factor for cardiovascular disease, cognitive decline, and other health issues. Methylation — specifically the conversion of homocysteine to methionine — is the primary mechanism for keeping homocysteine levels in a healthy range. Methylated B vitamins are essential for this process.

Q: How many capsules are in a bottle?A: 120 capsules per bottle. See the product label for the serving size and supply duration.

Q: Can I take MTHFR Daily if I’m pregnant or planning to become pregnant?A: Folate is critically important during pregnancy, and methylfolate is the preferred form for those with MTHFR variants. However, please consult your OB/GYN or healthcare provider before starting any new supplement during pregnancy or while trying to conceive.

Q: When will my order ship?A: Orders ship Monday through Friday with a 3 business day processing time. You will receive an email notification when your order ships.

Allergen Information: MTHFR Daily contains methylated B vitamins including methylfolate and methylcobalamin. Individuals who are sensitive to methyl donors (a small subset of those with MTHFR variants) may experience overmethylation symptoms such as anxiety or irritability at high doses. If you have any known sensitivities, are pregnant, or are taking medications, please consult your healthcare provider before use. Keep out of reach of children.